New applications of solid-state NMR to the extracellular matrix

Solid-state nuclear magnetic resonance (ssNMR) is a versatile technique that can provide structural information on complex materials in functionally-relevant states. An emerging area of ssNMR research concerns the extracellular matrix (ECM), a class of highly diverse biological materials composed of a heterogeneous mixture of molecular entities, including proteins, glycans, glycoproteins, and other biomolecules. These molecules show specific interactions and organisation at a range of length scales. SsNMR can contribute structural insight at the atomic length scale, potentially on ECM and ex vivo tissues samples with minimal processing or purification.


Dr Wing Ying Chow
Assistant Professor, Department of Physics, University of Warwick