We use solid-state NMR spectroscopy to bring new insight to biomolecules in the extracellular matrix that are relevant to human health and disease. We are based at the University of Warwick, UK.
News
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June 12, 2023
Archie and Marcus presented their MPhys project posters. Well done!
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May 15, 2023
Ananya has successfully passed the Progress Interview of her first six months of PhD work. Well done!
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May 12, 2023
David and Zac completed their BSc project vivas. Well done!
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October 20, 2022
Zac and David joined the lab as BSc project students today!
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October 17, 2022Ananya joined the lab as the first PhD student of WYChow Lab! Welcome to Warwick! Ananya did her MSc at IIT Ropar and BSc at Banars Hindu University. She will be working on new applications of ssNMR to extracellular matrices.
Research
New applications of solid-state NMR to the extracellular matrix
SsNMR is a versatile technique that can provide atomic-level structural information on complex materials in functionally-relevant states, with unique advantages for investigating the extracellular matrix (ECM).
ECM changes in Ehlers-Danlos Syndrome
Using ssNMR and cell culture of human fibroblast cell lines for Ehler-Danlos syndrome (EDS), we can understand molecular-level mechanisms that underlie key symptoms of this genetic disease.
Cell wall of fission yeast
Fission yeast is a key model organism in fungal and cell cycle research. SsNMR provide a means to quantify changes in cell wall composition upon novel and specific genetic manipulations.
ECM changes in ageing and cardiovascular disease
Using an isotopically-labelled mouse and mammalian cell culture, we developed ssNMR approaches to investigate ECM changes in ageing and cardiovascular disease.
Pigmentation in alkaptonuria
Alkaptonuria is a rare disease that can lead to servere pigmentation of various body tissues, which is associated with tissue degradation. While visually striking, the chemical nature of the pigment is still not well-understood. By characterizing in vitro-generated pigment using a variety of chemical techniques, we aim to understand the nature of the pigmentation species and illuminate new clinical approaches to prevent or reverse its formation.
People
Dr Wing Ying Chow
PhD Students
